Synthroid Side Effects: Common, Severe, Long Term

Both increased antiphospholipid antibodies and enhanced thrombin activity may contribute to hypercoagulable state in Grave’s disease (95). Unlike coronary heart disease, there have been few synthroid keppra epidemiologic studies on assessment of association between hypothyroidism/AIT and an increase in risk of cerebrovascular disease. These reports, mostly small studies, showed conflicting results and had methodological limitations (7, 88). Autoimmune pathology in AIT might itself affect cerebrovascular risk, as it has been previously shown for other autoimmune disorders (23).

SYNTHROID is indicated in adult and pediatric patients, including neonates, as a replacement therapy in primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) congenital or acquired hypothyroidism. One form of hypothyroidism is Hashimoto’s disease, where the body forms antibodies to its own thyroid gland cells, resulting in inflammation and possibly permanent low thyroid function. Another condition is hyperthyroidism, which is an overactive thyroid. An upset tummy and diarrhea are two potentially embarrassing but relatively common side effects of Synthroid. This should normalize out as your thyroid levels stabilize, but if you find yourself too nauseous to take your pill or are suffering from chronic diarrhea call your doctor right away, she says. Synthroid is the brand name for levothyroxine sodium, a synthetic thyroid hormone pill.

Although not all of these side effects may occur, if they do occur they may need medical attention. In contrast to the comments noted above, there are several studies that are in favor of a hypercoagulable state or a “No change” in hemostasis parameters. A 26yr old man presented to haematology with a short history of easy bruising. At MedicineNet, we believe it is important to take charge of your health through measures such as a living healthy lifestyle, practicing preventative medicine, following a nutrition plan, and getting regular exercise.

A proposed mechanism is direct effect of thyroid hormones as there are several studies in favor of a prothrombotic effect of thyroid hormones in the literature (19, 38, 44, 69). However, it has been unclear as to whether a deficiency in thyroid hormone levels or an elevated TSH (or both) contributes to alterations in coagulation parameters. An experimental study on rats did not show any significant effect of TSH on factors (F) II, FVII, FIX, FX, while T3 caused significantly reduced activities of the factors and T4 had the same effect on only FII (73).

• Reduce the SYNTHROID dosage or discontinue temporarily if signs or symptoms of overdosage occur.
• The authors believe that fibrinolytic activity substantially decreases when hypothyroidism gets more severe and thyroid hormone therapy to restore euthyroidism may be important in ameliorating the increased risk of cardiovascular events (62).
• These side effects may go away during treatment as your body adjusts to the medicine.

Keep a record of your symptoms

However, estrogen use appeared to negate the adverse effects of thyroid hormone on bone mineral density. The recommended starting daily dosage of SYNTHROID in pediatric patients with primary, secondary, or tertiary hypothyroidism is based on body weight and changes with age as described in Table 2. Titrate the dosage (every 2 weeks) as needed based on serum TSH or free- T4 until the patient is euthyroid see Important Considerations For Dosing. It has been hypothesized that patients with hypothyroidism and autoimmune thyroiditis are at increased risk of cardiovascular events and a recent meta-analysis revealed an increased risk of approximately 20% for coronary heart disease (93). The earliest reports on a link between thyroid disorders and coagulation abnormalities are from the early years of the past century (6-8). Since then, several studies have been conducted on thyroid function abnormalities and their effect on the hemostasis with contradictory results (9-19).

• The majority of the SYNTHROID dose is absorbed from the jejunum and upper ileum.
• “Taking Synthroid replaces the hormones that your thyroid should be making but, for whatever reason, isn’t.”
• The present report provides an updated and comprehensive report on hemostasis changes in hypothyroidism and autoimmune thyroid disorders.
• Your thyroid gland is one of the centers of your endocrine system, influencing how other important hormones are used.
• Approximately 80% of the daily dose of T4 is deiodinated to yield equal amounts of T3 and reverse T3 (rT3).
• However, the net effect of deficiency of thyroid hormone on fibrinolytic activity remains unclear (24, 75).

Important Administration Instructions

Subclinical hypothyroidism and autoimmune thyroiditis (AIT) has been reported in a patient with cerebral venous thrombosis (85). This is a case of acquired von Willebrand disease due to Hashimoto’s thyroiditis. It is the most common coagulopathy in hypothyroidism and is characterised clinically by easy bruising, epistaxis and mucosal bleeding and biochemically through elevated APTT, reduced Factor VIII and von Willebrand Factor.

Start at a lower starting dosage and increase the dosage every 4 to 6 weeks as needed based on clinical and laboratory response. SYNTHROID is indicated in adult and pediatric patients, including neonates, as an adjunct to surgery and radioiodine therapy in the management of thyrotropin-dependent well-differentiated thyroid cancer. Many drugs can inhibit Synthroid’s adsorption by the body; other medications may increase or decrease its effectiveness once it is adsorbed.

Understanding your symptoms and signs and educating yourself about health conditions are also a part of living your healthiest life. The links above will provide you with more detailed information on these medical conditions to help you inform yourself about the causes and available treatments for these conditions. Long-term carcinogenicity studies in animals to evaluate the carcinogenic potential of levothyroxine have not been performed. Studies to evaluate mutagenic potential and animal fertility have not been performed. If cardiac symptoms develop or worsen, reduce the SYNTHROID dose or withhold for one week and restart at a lower dose. Inquire whether patients are taking biotin or biotin-containing supplements.

For pregnant patients with pre-existing hypothyroidism, measure serum TSH and free-T4 as soon as pregnancy is confirmed and, at minimum, during each trimester of pregnancy. In pregnant patients with primary hypothyroidism, maintain serum TSH in the trimester-specific reference range. Your thyroid gland is one of the centers of your endocrine system, influencing how other important hormones are used. That’s why an underactive thyroid can affect so many functions throughout your body — and lead to such a wide range of weird and unpleasant symptoms. Thyroid hormones, including levothyroxine, should not be used either alone or with other therapeutic agents for the treatment of obesity or weight loss. Reduce the SYNTHROID dosage or discontinue temporarily if signs or symptoms of overdosage occur.

Our Synthroid Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects. Get medical help right away, if you have any of the symptoms listed above.